Resident Evil: Deadly Silence
- Developer:
- Genre:
- Publisher: Capcom
- Released:
- Official Website: http://ww2.capcom.com
Rhythm 'n Notes: Improve Your Music Skills
- Developer:
- Genre: Music & Dance
- Publisher: Agetec
- Released:
- Official Website: http://www.agetec.com
Rock Revolution
- Developer: HB Studios
- Genre: Music & Dance
- Publisher: Konami
- Released: Oct. 14, 2008
- Official Website: http://www.konami-data.com
Shrek The Third
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.shrekthethirdgame.com
Skate It
- Developer: Exient Entertainment
- Genre: Sports
- Publisher: EA
- Released: Nov. 19, 2008
- Official Website: http://www.skateit.ea.com
SNK vs. Capcom Card Fighters Clash DS
- Developer:
- Genre: Fighting
- Publisher: SNK
- Released:
- Official Website: http://www.snkplaymoreusa.com
Sonic Chronicles: The Dark Brotherhood
- Developer: Sega
- Genre: Role Playing
- Publisher: Sega
- Released: Sep. 30, 2008
- Official Website: http://www.sega.com
Space Invaders Extreme
- Developer: Taito
- Genre: Action
- Publisher: Square-Enix
- Released: Jun. 17, 2008
- Official Website: http://www.taito.co.jp
Spectrobes
- Developer:
- Genre:
- Publisher: Disney Interactive Studios
- Released:
- Official Website: http://adisney.go.com
Spider Man: Web of Shadows
- Developer: Activision
- Genre: Action
- Publisher: Activision
- Released: Oct. 21, 2008
- Official Website: http://seizecontrol.marvel.com
Spider-Man 2
- Developer:
- Genre:
- Publisher: Activision
- Released:
- Official Website: http://www.activision.com
Spider-Man 3
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.sm3thgame.com
Spongebob: Nicktoons Globs of Doom
- Developer: THQ
- Genre: Action
- Publisher: THQ
- Released: Oct. 20, 2008
- Official Website: http://www.sm3thgame.com
Sprung
- Developer:
- Genre:
- Publisher: Ubi Soft Entertainment
- Released:
- Official Website: http://www.ubi.com
Star Wars: The Force Unleashed
- Developer: n-Space
- Genre: Action
- Publisher: LucasArts
- Released: Sep. 16, 2008
- Official Website: http://www.lucasarts.com
