Samurai Warriors: Katana
- Developer:
- Genre: Shooter
- Publisher: Koei
- Released:
- Official Website: http://www.koei.com
Shrek The Third
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.shrekthethirdgame.com
Sonic and the Secret Rings
- Developer:
- Genre:
- Publisher: Sega
- Released:
- Official Website: http://www.sega.com
Sonic Riders: Zero Gravity
- Developer:
- Genre: Racing
- Publisher: Sega
- Released:
- Official Website: http://www.sega.com
Spider-Man 3
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.sm3thgame.com
Spider-Man: Friend or Foe
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.spiderman-friend-or-foe.com
Star Trek Conquest
- Developer:
- Genre: Strategy
- Publisher: Bethesda Softworks
- Released:
- Official Website: http://startrek.bethsoft.com
Strong Bad's Cool Game for Attractive People: Episode 1 - Homestar Ruiner
- Developer: Tell Tale Games
- Genre: Adventure
- Publisher: Tell Tale Games
- Released: Aug. 11, 2008
- Official Website: http://www.telltalegames.com
Super Mario Galaxy
- Developer:
- Genre: Platform
- Publisher: Nintendo
- Released:
- Official Website: http://www.supermariogalaxy.com
Super Monkey Ball: Banana Blitz
- Developer:
- Genre:
- Publisher: Sega
- Released:
- Official Website: http://www.sega.com
Super Paper Mario
- Developer:
- Genre:
- Publisher: Nintendo
- Released:
- Official Website: http://www.nintendo.com
Super Smash Bros. Brawl
- Developer:
- Genre: Fighting
- Publisher: Nintendo
- Released:
- Official Website: http://www.smashbros.com
Super Swing Golf
- Developer:
- Genre:
- Publisher: Tecmo
- Released:
- Official Website: http://www.nintendo.com
