Sonic Riders: Zero Gravity
- Developer:
- Genre: Racing
- Publisher: Sega
- Released:
- Official Website: http://www.sega.com
Spider Man: Web of Shadows
- Developer: Activision
- Genre: Action
- Publisher: Activision
- Released: Oct. 21, 2008
- Official Website: http://seizecontrol.marvel.com
Spider-Man 3
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.sm3thgame.com
Spider-Man: Friend or Foe
- Developer:
- Genre: Action
- Publisher: Activision
- Released:
- Official Website: http://www.spiderman-friend-or-foe.com
Spongebob: Nicktoons Globs of Doom
- Developer: THQ
- Genre: Action
- Publisher: THQ
- Released: Oct. 20, 2008
- Official Website: http://www.spiderman-friend-or-foe.com
Star Trek Conquest
- Developer:
- Genre: Strategy
- Publisher: Bethesda Softworks
- Released:
- Official Website: http://startrek.bethsoft.com
Star Wars: The Clone Wars - Lightsaber Duels
- Developer: Krome Studios
- Genre: Adventure
- Publisher: LucasArts
- Released: Nov. 11, 2008
- Official Website: http://www.lucasarts.com
Star Wars: The Force Unleashed
- Developer: Krome Studios
- Genre: Action
- Publisher: LucasArts
- Released: Sep. 16, 2008
- Official Website: http://www.lucasarts.com
Strong Bad's Cool Game for Attractive People: Episode 101 - Homestar Ruiner
- Developer: Tell Tale Games
- Genre: Adventure
- Publisher: Tell Tale Games
- Released: Aug. 11, 2008
- Official Website: http://www.telltalegames.com
Strong Bad's Cool Game for Attractive People: Episode 102 - Strong Badia the Free
- Developer: Tell Tale Games
- Genre: Adventure
- Publisher: Tell Tale Games
- Released: Sep. 15, 2008
- Official Website: http://www.telltalegames.com
Strong Bad's Cool Game for Attractive People: Episode 103 - Baddest of the Bands
- Developer: Tell Tale Games
- Genre: Adventure
- Publisher: Tell Tale Games
- Released: Oct. 27, 2008
- Official Website: http://www.telltalegames.com
Super Mario Galaxy
- Developer:
- Genre: Platform
- Publisher: Nintendo
- Released:
- Official Website: http://www.supermariogalaxy.com
Super Monkey Ball: Banana Blitz
- Developer:
- Genre:
- Publisher: Sega
- Released:
- Official Website: http://www.sega.com
Super Paper Mario
- Developer:
- Genre:
- Publisher: Nintendo
- Released:
- Official Website: http://www.nintendo.com
